Research Interests:
Our research activities are mainly in the areas of nucleic acid biochemistry, protein biochemistry, peptide/protein chemistry, bioanalytical chemistry, chemical biology, and bioengineering. Our research aim is to develop next-generation platform for disease diagnostics and therapy. To realize this aim, we are interested in playing with Nature's building blocks, peptide, protein, DNA and RNA.
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Topics of interest:
Fluorescent hairpins, peptide/protein chemistry, aptamer, antibody delivery, antibody mimics
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My research experiences focus on protein biochemistry, peptide chemistry, and nucleic acid chemistry. My background in peptide chemistry includes drug delivery and protein modifications, where I have developed and applied cyclized cell-penetrating peptides (CPPs) to enhance the cellular delivery of biomolecules. Notably, I devised a novel method for efficient CPP cyclization, significantly improving the cellular uptake of drugs. Additionally, I systematically investigated transamination using membrane-bound dipeptide arrays and a proteomics approach, contributing to a more predictable application of transamination for protein modifications. Furthermore, I have significant experience in developing nucleic acid-based tools, such as aptamers and molecular beacons, targeting mRNA, proteins, and small molecules. My background in protein biochemistry includes investigating novel functions in serine proteases and designing protein-based nanoparticles. Additionally, I have accumulated experience in developing nucleic acid nanostructures. These endeavors have resulted in collaborations, project administration, and peer-reviewed publications. Currently, my research interests focus on designing peptide and nucleic acid probes for biomolecular recognition, which aligns seamlessly with my prior work in peptide, aptamer, and protein research. I possess the ability to construct realistic research plans, establish timelines and budgets, and emphasize the importance of effective communication among project members.
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